To setup your email for your site.

The following is for Outlook 2013 - other cases will be similar.

Account Settings

Go to File>Account Settings>New
Choose Email account then choose Manually configure server settings (at the bottom)
Choose Internet email then enter Internet Email Settings:

Your Name - this shows recipients who the email is from
Email address - this is the address that will be used when recipients hit reply

Server Information

Account Type:  POP3
Incoming (POP3) server: mail.<domain> (e.g.  mail.cobourginternet.com, or mail.mydomain.com)
Outgoing (SMTP) Server: mail.<domain> (e.g.  mail.cobourginternet.com, or mail.mydomain.com)
Logon name: use full email address
Check remember password
Do NOT select Logon Using Secure password authentication. Be sure your user name is lowercase and password has upper or lowercase as required.

Click More Settings

Under Outgoing Server Tab

Check "My outgoing Server (SMTP) requires authentication"
Note: if your email settings (e.g. on your phone) do not give a "require authentication" option, they may  offer "require sign-in".  If so, use that option and provide the same user name and password as required for receive.  I needed to do this on my Android phone.

Use same settings as my incoming mail server
Do not check  "Requires Secure Password Authentication (SPA)"
Do not check: "Logon to incoming mail server before sending email"

Under Advanced

Settings for Secure

Check “This server requires an encrypted connection”.
POP3 Port incoming port 995
[OR for IMAP, incoming port 993]
The outgoing (SMTP) port is 465
For “Use the following type of encrypted connection” choose SSL or SSL/TLS.

For POP3, if you want to also access email on a separate computer (e.g. also on a phone), then check
"Leave a copy of messages on the server". The number of days should usually be small - e.g.
2 days - this is especially true if you have a large number of large emails daily.

Special cases

If your Internet Service Provider (ISP) is Bell, Sympatico or Airnet and the above does not work for sending emails, then wherever there is a box that requires outgoing email settings, use your Bell (or sympatico etc) information. You will be setting up to send via Bell and receive by the domain account.
If you have a problem, you will need to call Bell support.

The reason they do this is to minimize the chance that you might send spam from their servers.

Google Ad